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Düsseldorf, Germany, Feb. 4, 2021 – The innovative drug candidate PRI-002 against Alzheimer’s dementia will enter further clinical testing in patients.
The Federal Agency for Disruptive Innovation will support the future development of drug candidate PRI-002 for Alzheimer’s dementia. This was decided by the agency at its board meeting, on Feb. 4, 2021.
“The drug candidate PRI-002 realizes a completely new and highly innovative anti-prionic mechanism of action. It is able to break down the neurotoxic Abeta oligomers in the brain and convert them into harmless monomers,” explains Dieter Willbold, Professor of Physical Biology at Heinrich Heine University in Düsseldorf and Director of the Institute of Structural Biochemistry (IBI-7) at Forschungszentrum Jülich. He is also member of Priavoid’s Supervisory Board and founder of Priavoid. Other compounds in the Priavoid pipeline also exhibit this mechanism. All specifically designed active ingredients consist of D-enantiomeric amino acid building blocks. “Priavoid is using the anti-prionic mechanism of action with the D-peptide platform technology for drug development against additional neurodegenerative diseases,” continues Prof. Dr. Dr. h.c. Detlev Riesner, co-founder of the biotech companies Qiagen and Evotec and Chairman of the Supervisory Board of Priavoid. Professor Stanley Prusiner, University of California, San Francisco (UCSF) and 1997 Nobel Laureate for the prion research he founded, is delighted that the application of the concept of prions to Alzheimer’s disease is now expected to lead to a breakthrough in treatment. Professor Prusiner has been a member of Priavoid’s supervisory board since the beginning of December 2020. The D-enantiomeric active ingredients are very stable in the human body and can therefore be administered orally as tablets or capsules. “This is a very patient convenient route of administration especially for elder patients”, stated Dagmar Jürgens, Director of Clinical Research at Priavoid. “We will intensively pursue the development of our platform to provide patients with a treatment for neurodegenerative diseases as soon as possible” said Philipp Bürling, CEO of Priavoid.
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About Priavoid
Priavoid’s novel class of orally available all-D-peptide therapeutics detangle neurotoxic oligomer species to inhibit and reverse disease-specific protein aggregation in neurodegenerative disorders. We aim to establish clinical proof-of-concept through our lead program, PRI-002, which will complete a Phase 2 trial in Alzheimer’s disease in 2026. Priavoid has built a focused pipeline of detangler compounds that are non-immunogenic and reach their oligomer targets in the brain and inside the affected cells. Our goal is to develop disease-modifying therapies that address the underlying biology of neurodegeneration and drive meaningful clinical benefit for patients.